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Ors approved the final version of the manuscript. Acknowledgments--We thank Sofia Pustylnik for generating the stathmin-GFP construct, Carlo Dumpit for assistance with SEM analysis, Urja Naik for assistance with C3bi-sRBC binding assays, and Umama Siddiqi for helping with NF- B translocation analysis. We also thank Dr. He Song Sun for critical reading of the manuscript.
THE JOURNAL OF BIOLOGI
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To the cell surface (Fig. 7). Continued signaling through TLR4 is important for NF- B-mediated gene expression and secretion of pro-inflammatory cytokines in macrophages during a pathogenic challenge (9). Here we show that stathmin can modulate this sustained signaling, likely by affecting the stability of MT to enhance intracellular trafficking of receptor-containing vesicles, MMPs, and cytokines
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