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The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory area but lacked the zinc finger DNA-binding area, and so the truncated Ex4a(+)WT1 isoform retained the ability to interact with the transcriptional co-activators but misplaced a chance to bind to promoter of downstream targets. Past experiments have shown that the N-terminal domainPLOS One particular |
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