After a decrease in Biotin Price in Q4 2021, the price trend of Biotin in the first quarter of 2022 demonstrated an upward trajectory across the North American region. Biotin prices gradually increased from the second week of January from USD452965/MT to USD464690/MT in March 2022. Demand from the downstream nutraceutical and pharmaceutical industries remained high throughout the quarter. Increased maritime freight rates, as well as high raw material costs in Asia, have aided the country's price trend. The protracted port bottleneck and disrupted supply caused by China's zero-covid policy, on the other hand, had a severe impact on Biotin market across the country. The spike in US oil output that began in Q4 2021 has maintained the pressure on downstream markets high.